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S-Adenosylmethionine has been shown to increase hepatic glutathione levels in cats and dogs. Glutathione is a potent antioxidant that protects hepatic cells from toxins and death. A study found that low liver glutathione concentrations are common in dogs and cats with decreased hepatobiliary function. Denamarin is recommended to improve hepatic glutathione levels in patients to help maintain and protect liver function. Denamarin may also be used in other areas of tissue oxidant injury and RBC fragility caused by certain toxins or drugs which are related to reduced glutathione concentrations. Denamarin’s mechanism of action, however, goes beyond increasing glutathione levels, in that S-Adenosylmethionine has also been shown to protect liver cells from cell death and may be useful in cell regeneration. A study has also shown that S-Adenosylmethionine may improve bile flow in cats.Several supplements are promoted for improving depression. Examples include St. John's wort, 5-hydroxytryptophan (5-HTP), SAMe, fish oil, and L-theanine. Although these supplements may have mild antidepressant properties, it is important to remember that depression is a serious condition that needs proper evaluation and treatment under the care of a physician. It is also important to note that these supplements are not regulated by the FDA; their safety and efficacy have not been proven in large clinical studies, and they may interact with other drugs. Call your doctor at once if you have a serious side effect such as:

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